linusbert
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from chris masterjohns blog: https://chrismasterjohnphd.substack.com/p/is-vitamin-c-destroying-your-mitochondria
having some interesting views about vitamin c and how much is too much or helpful and how it influences copper metabolism and q10.
also this piece from another person is intersting about toxic supplements. i talk repeatedly about this that supplement industry is putting bad quality products potentially toxic out there.
though the author of the blog certainly took the black pill, i dont think it can be generalized like that, but great care must be taken with supplements, even plain vitamin C.
in general, stay away from everything made and sourced from china. and look for great quality ingredients, for example creatine and creapure, carnitine and carnipure, vitamin C and quali-c etc.
https://chemtrails.substack.com/p/vitamin-c-is-mold-corn-syrup-chemicals
also he does cite bad quality studies, for example linus pauling claimed that IV vitamin C does treat well against cancer, where as the study says that it didnt, but the study didnt use high dose IV but oral. as of today medicine is using again high dose IV vitamin C for cancer treatment. so pauling was right on that point.
also the vitamin C pauling used was produced differently, nowadays its a product from bacteria or fungi. back then they used extraction and refine processes, heat and stuff. and i think the type of C pauling used was sodium ascorbate (but on that i am not sure anymore, cant find the paper where i read that).
in general i would say he is like 80..90% right.
having some interesting views about vitamin c and how much is too much or helpful and how it influences copper metabolism and q10.
In Does CoQ10 Deserve a Spot on Your Longevity Plan?, I pointed out that phenylalanine hydroxylase is inhibited by the concentrations of vitamin C achieved by repeatedly taking 3 grams orally or by using intravenous vitamin C.
Phenylalanine hydroxylase is needed to convert phenylalanine to tyrosine, and tyrosine is the precursor to the “head” of coenzyme Q10.
Thus, it is very likely that such use of vitamin C inhibits CoQ10 synthesis.
In Vitamin C, Whole Food Vs. Synthetic: Does It Matter?, I covered a study suggesting 500 milligrams of vitamin C taken three times a day with meals for two months lowers serum copper by 5% and lowers ceruloplasmin by 25%. This raises the possibility that taking 1500 milligrams of vitamin C per day with meals decreases copper status, which would be expected to decrease the availability of copper to form complex IV of the mitochondrial respiratory chain. Every oxygen molecule that you use to generate energy is tightly held between a heme iron and a copper ion until it receives the protons and electrons needed to become water. Oxygen is what powers nearly all of metabolism in this way, and that cannot be done without sufficient copper.
As I pointed out in Cancer, IV Drips, and the Glutathione-Vitamin C Connection, vitamin C in excess of the many factors needed for its recycling will generate oxalate, which itself is a mitochondrial toxin that inhibits citric acid cycle activity by 48% at concentrations found on the high end of the “normal” range.
As also pointed out in Cancer, IV Drips, and the Glutathione-Vitamin C Connection, high-dose intravenous vitamin C acts as a pro-oxidant outside the context of sepsis, and this is probably true of repeated oral megadosing. This has the potential to cause oxidative damage to mitochondria. Moreover, oxidation of the glutathione pool has the potential to interfere with the synthesis of mitochondrial proteins.
On the other hand, several case reports (here and here) show that one gram of vitamin C taken every six hours (alongside 10 milligrams of menadione, which I would replace with MK-4 can help mitigate impairments in complex III of the respiratory chain by delivering electrons to a site after complex III, most likely to cytochrome C, so that some ATP can still be made through the activity of complex IV (which of course might stop working if you induce a copper deficiency).
The negative effect on copper absorption can probably be avoided simply by taking high-dose vitamin C away from meals. However, that does not stop it from acting as a pro-oxidant, generating oxalate, or interfering with CoQ10 synthesis.
This is not to say that vitamin C at high doses will necessarily wreck your mitochondria. It is, rather, to say that doses above 400 milligrams should be used with greater caution.
When vitamin C is used at high doses to rewire the respiratory chain it can help if you need it. This is partially analogous to methylene blue, which has a broader number of ways it can rewire the respiratory chain than vitamin C, but also fulfills the principle that it helps you if you need it and hurts you if you don’t.
The best way to test the safety and utility would be to use the Comprehensive Screening for Energy Metabolism to ensure that oxalate levels are not elevated, to look for evidence of a complex III impairment, and to determine its cause, if found, to see if there are other more effective ways to fix it. It would would also be helpful to verify that high-dose vitamin C does not increase resting fasted lactate. Lactate would likely rise in response to a CoQ10 or copper deficit, but could conceivably decrease in response to oxalate inhibiting the citric acid cycle.
If you don’t have a specific reason to megadose vitamin C, it is best to stick to the doses you could get from a very vitamin C-rich whole-foods diet.
Phenylalanine hydroxylase is needed to convert phenylalanine to tyrosine, and tyrosine is the precursor to the “head” of coenzyme Q10.
Thus, it is very likely that such use of vitamin C inhibits CoQ10 synthesis.
In Vitamin C, Whole Food Vs. Synthetic: Does It Matter?, I covered a study suggesting 500 milligrams of vitamin C taken three times a day with meals for two months lowers serum copper by 5% and lowers ceruloplasmin by 25%. This raises the possibility that taking 1500 milligrams of vitamin C per day with meals decreases copper status, which would be expected to decrease the availability of copper to form complex IV of the mitochondrial respiratory chain. Every oxygen molecule that you use to generate energy is tightly held between a heme iron and a copper ion until it receives the protons and electrons needed to become water. Oxygen is what powers nearly all of metabolism in this way, and that cannot be done without sufficient copper.
As I pointed out in Cancer, IV Drips, and the Glutathione-Vitamin C Connection, vitamin C in excess of the many factors needed for its recycling will generate oxalate, which itself is a mitochondrial toxin that inhibits citric acid cycle activity by 48% at concentrations found on the high end of the “normal” range.
As also pointed out in Cancer, IV Drips, and the Glutathione-Vitamin C Connection, high-dose intravenous vitamin C acts as a pro-oxidant outside the context of sepsis, and this is probably true of repeated oral megadosing. This has the potential to cause oxidative damage to mitochondria. Moreover, oxidation of the glutathione pool has the potential to interfere with the synthesis of mitochondrial proteins.
On the other hand, several case reports (here and here) show that one gram of vitamin C taken every six hours (alongside 10 milligrams of menadione, which I would replace with MK-4 can help mitigate impairments in complex III of the respiratory chain by delivering electrons to a site after complex III, most likely to cytochrome C, so that some ATP can still be made through the activity of complex IV (which of course might stop working if you induce a copper deficiency).
The negative effect on copper absorption can probably be avoided simply by taking high-dose vitamin C away from meals. However, that does not stop it from acting as a pro-oxidant, generating oxalate, or interfering with CoQ10 synthesis.
This is not to say that vitamin C at high doses will necessarily wreck your mitochondria. It is, rather, to say that doses above 400 milligrams should be used with greater caution.
When vitamin C is used at high doses to rewire the respiratory chain it can help if you need it. This is partially analogous to methylene blue, which has a broader number of ways it can rewire the respiratory chain than vitamin C, but also fulfills the principle that it helps you if you need it and hurts you if you don’t.
The best way to test the safety and utility would be to use the Comprehensive Screening for Energy Metabolism to ensure that oxalate levels are not elevated, to look for evidence of a complex III impairment, and to determine its cause, if found, to see if there are other more effective ways to fix it. It would would also be helpful to verify that high-dose vitamin C does not increase resting fasted lactate. Lactate would likely rise in response to a CoQ10 or copper deficit, but could conceivably decrease in response to oxalate inhibiting the citric acid cycle.
If you don’t have a specific reason to megadose vitamin C, it is best to stick to the doses you could get from a very vitamin C-rich whole-foods diet.
also this piece from another person is intersting about toxic supplements. i talk repeatedly about this that supplement industry is putting bad quality products potentially toxic out there.
though the author of the blog certainly took the black pill, i dont think it can be generalized like that, but great care must be taken with supplements, even plain vitamin C.
in general, stay away from everything made and sourced from china. and look for great quality ingredients, for example creatine and creapure, carnitine and carnipure, vitamin C and quali-c etc.
https://chemtrails.substack.com/p/vitamin-c-is-mold-corn-syrup-chemicals
also he does cite bad quality studies, for example linus pauling claimed that IV vitamin C does treat well against cancer, where as the study says that it didnt, but the study didnt use high dose IV but oral. as of today medicine is using again high dose IV vitamin C for cancer treatment. so pauling was right on that point.
also the vitamin C pauling used was produced differently, nowadays its a product from bacteria or fungi. back then they used extraction and refine processes, heat and stuff. and i think the type of C pauling used was sodium ascorbate (but on that i am not sure anymore, cant find the paper where i read that).
in general i would say he is like 80..90% right.
If you read my posts Vitamin D is Rat Poison and Vitamin B is Cyanide, you know I was a huge advocate for synthetic Vitamins and Supplements because of the advice given to me through Bodybuilding forums. The advice for people who are as toned as they can get, but struggling to put on muscle, was to supplement, supplement, supplement; load up on synthetic Vitamins and Protein Powder. Not once did I ever question what was in these products. I had not the slightest clue what the ingredients were, let alone how Supplements are made. For nearly a decade, every morning I voluntarily dosed myself with products from my impressive 6-foot wall shelf, loaded to the brim with expensive little glass containers of drops, jugs of powder and bottles of pills, all referred to as “Nutritional Supplements”.
And, before we embark on this journey, I will say it a 100th time, if these chemicals are helping you, GREAT! TAKE THEM!
Subscribe
After I finished writing my last post, Vitamin B12 is Cyanide, I was laying in bed that evening, wondering why we question vaccines, pharmaceuticals and ingredients in food but never question Vitamins. I then thought to myself, “What do people think Vitamins are?”. Like, let’s say you ask someone, “What are Vitamins made from?”, what would they reply? This made me reflect on what I thought Vitamins were.
Call me foolish, call me a moron, call me whatever you want, but prior to researching Vitamins, I seriously thought Vitamin C was taken out of oranges or something. I guess, in my head, I pictured a scientist in a lab coat sticking a syringe into a piece of fruit to extract the Vitamins. Now that I type it out loud, it sure does sound dumb AF. Am I the only one who thought this? Or does everyone think this?
READ MORE IN THE LINK
And, before we embark on this journey, I will say it a 100th time, if these chemicals are helping you, GREAT! TAKE THEM!
Subscribe
After I finished writing my last post, Vitamin B12 is Cyanide, I was laying in bed that evening, wondering why we question vaccines, pharmaceuticals and ingredients in food but never question Vitamins. I then thought to myself, “What do people think Vitamins are?”. Like, let’s say you ask someone, “What are Vitamins made from?”, what would they reply? This made me reflect on what I thought Vitamins were.
Call me foolish, call me a moron, call me whatever you want, but prior to researching Vitamins, I seriously thought Vitamin C was taken out of oranges or something. I guess, in my head, I pictured a scientist in a lab coat sticking a syringe into a piece of fruit to extract the Vitamins. Now that I type it out loud, it sure does sound dumb AF. Am I the only one who thought this? Or does everyone think this?
READ MORE IN THE LINK
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